4-Toluenesulfonyl chloride → HCID 67457973, compound

Participants

Reaction Steps

To a suspension of 0.798 mg (1.93 mmol) 1-(3-bromo-2-hydroxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-thiourea in 8 ml THF, 0.197 g (4.8 mmol) NaOH (in 5 ml water) and 0.419 g (2.12 mmol) toluene-4-sulfonyl chloride are added. The reaction mixture is stirred at room temperature for 1.5 h. Then the reaction mixture is concentrated in vacuo. To the residue EtOAc and sat. NaCl-solution are added and the layers are separate. The water layer is extracted 3× with EtOAc. The combined organic layers are washed with water, dried over MgSO4, filtered and the filtrate is concentrated in vacuo. The residue is stirred in diethyl ether, filtered and dried to afford the title compound.

Provenance & Evidence