Ethyl Acetate → HCID 178493063, compound

Participants

Reaction Steps

A solution of 0.182 g (0.243 mmol) N-{2-amino-4-[2-(3,4,5-trimethoxy-phenylamino)-benzooxazol-7-yl]-phenyl}-formamide in 3 ml acetic acid is stirred at 100° C. for 1 h. Then EtOAc is added to the reaction mixture and the organic layer is washed with 4N NaOH solution (2×) and with water (2×), dried over MgSO4, filtered and the filtrate is concentrated in vacuo. The residue is purified by chromatography (silicagel, EtOAc=>EtOAc:MeOH=95:5) to afford the title compound as an orange solid. Rt=1.86 min (Waters Symmetry C8, 2.1×50 mm, detection 210-250 nM, 5% to 100% CH3CN in H2O in 2 min+0.05% TFA, flow rate 1.0 ml/min); MS: 417 (M+1)+; m.p. 150-156° C.

Provenance & Evidence