Potassium ethylxanthate → HCID 178527807, compound

HRID 469817Notes

Reaction equation

HRID 469817 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([Br:8])[C:3]=1[OH:9].CCO[C:13]([S-])=[S:14].[K+]>CCO>[Br:8][C:4]1[C:3]2[O:9][C:13]([SH:14])=[N:1][C:2]=2[CH:7]=[CH:6][N:5]=1

Participants

4

Reactant 2

HCID 2735045Potassium ethylxanthateHCID 867622171013643-07-6

Product 1

HCID 178527807HCID 178527807, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.34 g (7.09 mmol) 4-amino-2-bromo-pyridin-3-ol are dissolved in 13 ml EtOH and 1.86 g (11.3 mmol) potassium ethyl xanthogenate are added. This mixture is stirred for 18 h at reflux temperature. After cooling to room temperature, the reaction mixture is concentrated in vacuo and 5 ml water are added. With the addition of acetic acid, a pH of 5 is adjusted. The product starts to crystallize and is filtered off, washed 2× with water and dried to afford the title compound.

Workup

  1. temperatureat reflux temperature
  2. concentrationthe reaction mixture is concentrated in vacuo and 5 ml water
  3. additionare added
  4. additionWith the addition of acetic acid
  5. customto crystallize
  6. filtrationis filtered off
  7. washwashed 2× with water
  8. customdried

Sources & evidence

ORD record
ord-f0124d5faa6e4d60b79677e78c65f173
Source dataset
uspto-grants-2014_01
Patent number
US08629168B2

Reaction notes

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