HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 4-amino-N,N,2-trimethylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | N,N,2-trimethyl-4-nitrobenzamide | HCID 62604610 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-amino-N,N,2-trimethylbenzamide | HCID 53622912 | — |
Reaction Steps
A solution of 1.7 g (8.16 mmol) 2,N,N-trimethyl-4-nitro-benzamide in 45 ml MeOH:THF=1:1 is hydrogenated in the presence of 0.2 g 10% Pd/C (Fluka 75990). The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo to afford the crude title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629168B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-8cd8849841184a608b42eb6ad4f7817e |
| Source note | uspto-grants-2014_01 |