Water → 4-{7-[4-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-3,5-difluoro-phenyl]-benzooxazol-2-ylamino}-2,N,N-trimethyl-benzamide

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Reaction Conditions

Reaction Steps

A solution of 0.1 g (0.267 mmol) 4-(7-bromo-benzooxazol-2-ylamino)-2,N,N-trimethyl-benzamide, 0.114 g (0.294 mmol) 4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-thiomorpholine 1,1-dioxid and 174 mg K3PO4 are dissolved in 5 ml 1,2-dimethoxy-ethane, water (0.1 ml) is added and a stream of argon is bubbled through the mixture in order to exclude oxygen from the reaction mixture. Tetrakis (triphenylphosphine) palladium (0.0095 g, 0.0082 mmol) is added and the reaction mixture is stirred at 100° C. for 8 h. After that the reaction mixture is poured on water and extracted 3× with EtOAc. The combined organic layers are washed with water and saturated NaCl solution, dried over MgSO4, filtered and the filtrate is concentrated in vacuo. The residue is purified by chromatography (silicagel, EtOAc), followed by recrystallisation diethylether/methanol to afford the title compound as white crystals. Rt=2.13 min (Waters Symmetry C8, 2.1×50 mm, detection 210-250 nM, 5% to 100% CH3CN in H2O in 2 min+0.05% TFA, flow rate 1.0 ml/min); MS: 555 (M+1)+.

Provenance & Evidence