4-[4-(2-Methoxy-ethyl)-piperazin-1-yl]-3-methyl-phenylamine → (7-Bromo-benzooxazol-2-yl)-{4-[4-(2-methoxy-ethyl)-piperazin-1-yl]-3-methyl-phenyl}-amine

HRID 469831Notes

Reaction equation

HRID 469831 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=2[CH3:18])[CH2:7][CH2:6]1.[Br:19][C:20]1[C:28]2[O:27][C:26](SC)=[N:25][C:24]=2[CH:23]=[CH:22][CH:21]=1>>[Br:19][C:20]1[C:28]2[O:27][C:26]([NH:17][C:14]3[CH:15]=[CH:16][C:11]([N:8]4[CH2:9][CH2:10][N:5]([CH2:4][CH2:3][O:2][CH3:1])[CH2:6][CH2:7]4)=[C:12]([CH3:18])[CH:13]=3)=[N:25][C:24]=2[CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 666173884-[4-(2-Methoxy-ethyl)-piperazin-1-yl]-3-methyl-phenylamineHCID 674568117-Bromo-2-(methylthio)benzo[d]oxazole

Product 1

HCID 67457843(7-Bromo-benzooxazol-2-yl)-{4-[4-(2-methoxy-ethyl)-piperazin-1-yl]-3-methyl-phenyl}-amine

Procedure

The title compound is prepared from 4-[4-(2-methoxy-ethyl)-piperazin-1-yl]-3-methyl-phenylamine and 7-bromo-2-methylsulfanyl-benzooxazole using methodology described in the preparation of example 64.

Workup

  1. customdescribed in the preparation of example 64

Sources & evidence

ORD record
ord-41d4629a4fbb4cbd835457df591fbc9d
Source dataset
uspto-grants-2014_01
Patent number
US08629168B2

Reaction notes

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