HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 4-[4-(2-Methoxy-ethyl)-piperazin-1-yl]-3-methyl-phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1-(2-Methoxy-ethyl)-4-(2-methyl-4-nitro-phenyl)-piperazine | HCID 67458825 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[4-(2-Methoxy-ethyl)-piperazin-1-yl]-3-methyl-phenylamine | HCID 66617388 | — |
Reaction Steps
A solution of 0.85 g (3.04 mmol) 1-(2-methoxy-ethyl)-4-(2-methyl-4-nitro-phenyl)-piperazine in 20 ml MeOH:THF=1:1 is hydrogenated in the presence of 0.2 g 10% Pd/C (Engelhard 4505). The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo to afford the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629168B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-5cf1bcbbf98a4561a3630887a21c097b |
| Source note | uspto-grants-2014_01 |