Trifluoroacetic acid → HCID 67456908, compound

Participants

Reaction Steps

A mixture of 0.146 g (0.224 mmol) 4-{4-[2-(4-diethylcarbamoyl-3-methyl-phenylamino)-benzooxazol-7-yl]-2,6-difluoro-benzyl}-piperazine-1-carboxylic acid tert-butyl ester, 2 ml trifluoroacetic acid and 10 ml dichloromethane is stirred at room temperature for 2 h. Then the reaction mixture is poured on water and extracted 3× with EtOAc. The combined organic layers are washed with water and saturated NaCl solution, dried over MgSO4, filtered and the filtrate is concentrated in vacuo. The residue is purified by chromatography (silicagel, 100% EtOAc=>EtOAc:MeOH=1:1+1% triethylamine) to afford 0.04 g of the title compound as a white solid.

Provenance & Evidence