反应详情

To a solution of 4.55 g (27.2 mmol) (2-methyl-4-nitro-phenyl)-methanol 10.8 g (40.8 mmol) triphenylphosphine and 13.7 g (40.8 mmol) carbon tetrabromide is added at 0° C. The reaction mixture is stirred at room temperature for 1 h. After that the reaction mixture is filtered and the filtrate is concentrated in vacue. The residue is purified by chromatography (silicagel, 100% hexane=>100% EtOAc) to afford the title compound as an oil.

1. filtrationAfter that the reaction mixture is filtered
2. concentrationthe filtrate is concentrated in vacue
3. customThe residue is purified by chromatography (silicagel, 100% hexane=>100% EtOAc)