HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 5-Amino-1,3-dimethyl-1,2-dihydropyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1,3-dimethyl-5-nitropyridin-2(1H)-one | HCID 4657526 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Amino-1,3-dimethyl-1,2-dihydropyridin-2-one | HCID 67456616 | — |
Reaction Steps
A solution of 1.0 g (5.77 mmol) 1,3-dimethyl-5-nitro-1H-pyridin-2-one in 40 ml MeOH:THF=1:1 is hydrogenated in the presence of 0.18 g 10% Pd/C (Engelhard 4505). The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo to afford the crude title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629168B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-cbf51a400c634a57b2cfd516b58e65b4 |
| Source note | uspto-grants-2014_01 |