反应详情

A solution of [4-(2-bromoethyl)phenyl]acetic acid (48.6 g., 0.2 mole) and sulfuric acid (1.5 ml.) in ethanol (400 ml.) is boiled under reflux for 6 hours. About 300 ml. of the ethanol is removed by distillation at reduced pressure. The residue is diluted with 400 ml. of water. The oily ester is taken up in ether, washed with water and brine, and dried over magnesium sulfate. Evaporation of the ether leaves the title compound as an oil which can be purified by distillation in vacuo.

1. temperatureunder reflux for 6 hours
2. customof the ethanol is removed by distillation at reduced pressure
3. additionThe residue is diluted with 400 ml
4. washwashed with water and brine
5. dry with materialdried over magnesium sulfate
6. customEvaporation of the ether