反应详情

To a suspension of 2,4-dichloroquinoline in MeOH (100 mL) was added sodium methoxide (50 g). The mixture was heated at reflux for 2 days. After cooling, the mixture was filtered. The filtrate was concentrated under reduced pressure to yield a residue that was dissolved in water and extracted with CH2Cl2. The combined organic layers were dried over Na2SO4 and concentrated to give 2,4-dimethoxyquinoline as a white solid (13 g, 74% over 2 steps).

1. temperatureThe mixture was heated
2. temperatureat reflux for 2 days
3. temperatureAfter cooling
4. filtrationthe mixture was filtered
5. concentrationThe filtrate was concentrated under reduced pressure
6. customto yield a residue that
7. extractionextracted with CH2Cl2
8. dry with materialThe combined organic layers were dried over Na2SO4
9. concentrationconcentrated