反应详情

To a refluxing solution containing 43.9 g (0.25 mole) of 3-chlorobenzoyl chloride in 120 ml. of dry benzene is added 30.0 g. (0.225 mole) of anhydrous aluminum chloride in several portions over a period of 10 minutes. When the reaction is complete, as indicated by vapor phase chromatographic (vpc) techniques, the mixture is cooled to 25° and diluted with ether. Extraction with dilute base is followed by thorough drying (magnesium sulfate) and concentration in vacuo. Final purification is effected by recrystallization from ether-hexane to afford 13.7 g (0.06 mole) of 3-chlorobenzophenone, m.p. 84°14 85°.

1. temperaturethe mixture is cooled to 25°
2. extractionExtraction
3. additionwith dilute base
4. customby thorough drying
5. concentration(magnesium sulfate) and concentration in vacuo
6. customFinal purification
7. customis effected by recrystallization from ether-hexane