HCID 10998089, compound → 6-Amino-1-phenyl-1H-pyrimidine-2,4-dione

HRID 470157Notes

Reaction equation

HRID 470157 reaction equation
[C:1]([CH2:3][C:4]([NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:8])=[O:5])#[N:2]>[OH-].[Na+]>[NH2:2][C:1]1[N:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7](=[O:8])[NH:6][C:4](=[O:5])[CH:3]=1

Participants

3

Reactant 1

HCID 10998089HCID 10998089, compound

Product 1

HCID 7028786-Amino-1-phenyl-1H-pyrimidine-2,4-dioneYield 94.4%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

1-(2-Cyano-acetyl)-3-phenyl-urea (12.6 g, 62.1 mmol) was taken in 50 ml 2M sodium hydroxide (aq.) and stirred at room temperature for 2 h under LC-MS control. After cooling down by immersing in ice bath and neutralization with acetic acid and thus formed solids were separated by filtration, washed well with ice cold water and dried under high vacuum yielding white solids (11.9 g, 58.6 mmol, 94.4%).

Workup

  1. temperatureAfter cooling down
  2. customneutralization with acetic acid and thus formed solids were separated by filtration
  3. washwashed well with ice cold water
  4. customdried under high vacuum

Sources & evidence

ORD record
ord-1ecfc30e30ac4cfeb10b1bd63882eb4d
Source dataset
uspto-grants-2014_01
Patent number
US08629272B2

Reaction notes

Loading…