反应详情

温度

100 °C

Liquid ammonia (100 mL) was added to (1S,4R)-4-(4,7-difluoro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopent-2-enol (3-2) (220 mg, 0.6 mmol, 1 equiv). The resulting solution was heated in a high pressure vessel to 100° C. for 3 days. The mixture was then concentrated and purified via reverse phase chromatography (5-95% CH3CN/water with 0.1% TFA modifier) to yield (1S,4R)-4-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopent-2-enol (3-3) as a white solid. LRMS m/z (M+H) 235.0 found, 235.1 required.

1. concentrationThe mixture was then concentrated
2. custompurified via reverse phase chromatography (5-95% CH3CN/water with 0.1% TFA modifier)