HCID 178473441, compound → HCID 20384863, compound

HRID 47018Notes

Reaction equation

HRID 47018 reaction equation
[N:1]1([C:7]2[N:12]=[C:11]([NH:13][C:14](OCC)=[O:15])[N+:10]([O-:19])=[C:9]([NH:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C1(C)C=CC=CC=1>[N:1]1([C:7]2[CH:8]=[C:9]([NH:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])[N:10]3[O:19][C:14](=[O:15])[N:13]=[C:11]3[N:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 178473441HCID 178473441, compound

Product 1

HCID 20384863HCID 20384863, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

4.5 G. of diethyl 6-piperidino-2,4-pyrimidine-dicarbamate-3-oxide are treated under an argon atmosphere with 60 ml. of toluene and the mixture is heated to reflux for 12 hours. After cooling the mixture, the precipitate is filtered off and recrystallized from ether, there being obtained pure ethyl 5-piperidino-2-oxo-2H-[1,2,4]oxadiazolo[2,3-a]pyrimidine-7-carbamate, having a melting point of 209°-210° C. (decomposition).

Workup

  1. temperatureto reflux for 12 hours
  2. temperatureAfter cooling the mixture
  3. filtrationthe precipitate is filtered off
  4. customrecrystallized from ether, there

Sources & evidence

ORD record
ord-063afdf7cbaf40dbbe6466ff5357c40c
Source dataset
uspto-grants-1979_11
Patent number
US04176119

Reaction notes

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