HCID 90474469, compound → HCID 178455889, compound

HRID 47035Notes

Reaction equation

HRID 47035 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:12]([NH:14][CH2:15][C:16]([NH:18][C@@H:19]([C:30]([O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:31])[CH2:20][CH2:21][CH2:22][NH:23][C:24](=[NH:29])[NH:25][N+:26]([O-:28])=[O:27])=[O:17])=[O:13])[CH3:11])=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4].N1([C:68]2[CH:79]=[CH:78][C:74]([N+:75]([O-:77])=[O:76])=[CH:73][C:69]=2[N+:70]([O-:72])=[O:71])CCC[C@H]1C(N[C@H](C(NCC(O)=O)=O)CCC(=O)N)=O>>[NH:1]([C:68]1[CH:79]=[CH:78][C:74]([N+:75]([O-:77])=[O:76])=[CH:73][C:69]=1[N+:70]([O-:72])=[O:71])[C@H:2]([C:7]([NH:9][C@H:10]([C:12]([NH:14][CH2:15][C:16]([NH:18][C@@H:19]([C:30]([O:32][CH2:33][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1)=[O:31])[CH2:20][CH2:21][CH2:22][NH:23][C:24](=[NH:29])[NH:25][N+:26]([O-:28])=[O:27])=[O:17])=[O:13])[CH3:11])=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4]

Participants

3

Reactant 2

HCID 90474469HCID 90474469, compoundHCID 178455971Boc-Ile-Ala-Gly-D-Arg(NO2)-OBzl

Product 1

HCID 178455889HCID 178455889, compound

Procedure

Boc-Ile-Ala-Gly-D-Arg(NO2)-OBzl (900 mg, 1.4 m mol) was demasked with respect to the N-masking group, and coupled with DNP-Pro-Gln-Gly-OH (580 mg, 1.4 m mol) in the manner similar to that of Example 1, paragraph 7).

Sources & evidence

ORD record
ord-3e94378c851341e7aaa1fd6b0c1fb2a2
Source dataset
uspto-grants-1979_11
Patent number
US04176009

Reaction notes

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