1,2-Dichloroethane → HCID 136106406, compound

Participants

Reaction Steps

Et3N (0.079 mL, 0.568 mmol, 8.0 eq.) was added to a mixture containing the crude carboxylic acid salt 9c (0.071 mmol, 1.0 eq.), histamine.2HCl (16 mg, 0.085 mmol, 1.2 eq.), EDC (15 mg, 0.078 mmol, 1.1 eq.) and HOBt (11 mg, 0.078 mmol, 1.1 eq.) in dry DMF (2 mL) and stirred for 16 h. The reaction mixture was concentrated in vacuo and the residue was purified by flash chromatography [10% (5% aq NH4OH/MeOH)/DCM] to afford the title compound (Rf=0.40) as a light yellow powder (20.1 mg, 53%). ES-MS MH+ 530.30.

Provenance & Evidence