HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 5-(Methoxymethyl)pyridine-2,3-dicarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 46899675 | HCID 46899675 | — |
| Product | 5-(Methoxymethyl)pyridine-2,3-dicarboxylic acid | HCID 10998311 | — |
Reaction Steps
7.0 g (35 mmol) 5-chloromethyl-pyridine-2,3-dicarboxylic acid anhydride (Va) were dissolved in 165 g (5.16 mol) methanol at room temperature, causing formation of mono-esters. 14 g (350 mmol) NaOH (50% in water) were slowly added whereupon the temperature rose to 50° C. and carboxylate started to precipitate. Stirring was continued for additional 5 h at 65° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629279B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-474c3534e761469691a089eb2380848e |
| Source note | uspto-grants-2014_01 |