反应详情

温度

80 °C

A mixture of 2-bromo-3-fluoropyridine (1.05 g, 6.0 mmol), 4-cyanophenylboronic acid (0.882 g, 6.0 mmol), Pd(PPh3)4 (0.138 g, 0.12 mmol), and aqueous sodium carbonate solution (2M, 6 mL), in dioxane (6 mL) was degassed for 15 minutes. The mixture was sealed, heated to 80° C. for 12 hours, washed with water and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, concentrated and purified by chromatography to yield 4-(3-fluoropyridin-2-yl)benzonitrile (1.16 g, 89%).

1. customin dioxane (6 mL) was degassed for 15 minutes
2. customThe mixture was sealed
3. washwashed with water
4. extractionextracted with ethyl acetate
5. dry with materialThe organic layer was dried over magnesium sulfate
6. concentrationconcentrated
7. custompurified by chromatography