関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoate | HCID 67997044 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(2-(4-Cyanophenyl)pyridin-3-ylthio)-2-methylpropanoic acid | HCID 67997363 | 96.6% |
反応手順
A mixture of ethyl 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoate (0.137 g, 0.42 mmol), aqueous sodium hydroxide solution (1M, 1 mL) and methanol (2 mL) was stirred at 60° C. for 12 hours. The reaction mixture was concentrated to remove methanol, acidified and filtered to obtain 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoic acid as a white powder (0.121 g, 96%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08629278B2 |
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| 出典データセット | uspto-grants-2014_01 |
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| ORD ID | ord-2c608e5c93774fffbf61e71820397010 |
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| 出典メモ | uspto-grants-2014_01 |
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