HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 470385Generated: October 27, 2026
Hydrochloric Acid → Ethyl 2-(3-bromopyridin-2-ylthio)-2-methylpropanoate
https://huagongshe.com/reaction/470385
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Propanoic acid, 2-bromo-2-methyl-, ethyl ester | HCID 11745 | — |
| Reactant | HCID 178527856 | HCID 178527856 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-(3-bromopyridin-2-ylthio)-2-methylpropanoate | HCID 67997086 | 89.1% |
Reaction Steps
A mixture of 3-bromopyridine-2-thiol (189 mg, 1 mmol), ethyl-2-bromoisobutyrate (390 mg, 2 mmol) and sodium carbonate (159 mg, 1.5 mmol) in DMF (2 mL) was heated to 70° C. for 1 hour. The reaction mixture was neutralized with HCl aq. 1M and extracted with ethyl acetate. The organic layer was dried over Mg2SO4, concentrated and purified by chromatography to yield ethyl 2-(3-bromopyridin-2-ylthio)-2-methylpropanoate (0.271 g, 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08629278B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-5001ea4e52294d5389b03e554163792b |
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| Source note | uspto-grants-2014_01 |
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