HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 470391Generated: October 30, 2026
Sodium Carbonate → Methyl 2-[(5-bromopyrimidin-4-yl)sulfanyl]acetate
https://huagongshe.com/reaction/470391
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Methyl Thioglycolate | HCID 16907 | — |
| Reactant | 5-Bromo-4-chloropyrimidine | HCID 12270078 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 2-[(5-bromopyrimidin-4-yl)sulfanyl]acetate | HCID 66318500 | 84% |
Reaction Steps
A mixture of 4-chloro-5-bromopyrimidine (0.193 g, 1.0 mmol), methyl 2-mercaptoacetate (0.116 g, 1.1 mmol) and sodium carbonate (0.159 g, 1.5 mmol) in DMF (0.7 mL) was heated under microwave irradiation to 150° C. for 20 minutes. The mixture was washed with water, extracted with ethyl acetate and purified by chromatography to yield methyl 2-(5-bromopyrimidin-4-ylthio)acetate (0.22 g, 84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08629278B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-cbce5f89c4814e9392be2cbc3bffafff |
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| Source note | uspto-grants-2014_01 |
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