反应详情

A mixture of methyl 2-(4-(4-cyanonaphthalen-1-yl)pyrimidin-5-ylthio)acetate (22 mg, 0.065 mmol), aqueous sodium hydroxide solution (1M, 0.5 mL) and methanol (1 mL) was stirred at room temperature for 2 hours. Methanol was removed and aqueous sodium hydroxide solution (1M, 1 mL) and ethyl acetate (3 mL) were added. The aqueous layer was removed, acidified and extracted with ethyl acetate. The second organic layer was concentrated to dryness to yield 2-(4-(4-cyanonaphthalen-1-yl)pyrimidin-5-ylthio)acetic acid (19 mg, 91%).

1. customMethanol was removed
2. additionaqueous sodium hydroxide solution (1M, 1 mL) and ethyl acetate (3 mL) were added
3. customThe aqueous layer was removed
4. extractionextracted with ethyl acetate
5. concentrationThe second organic layer was concentrated to dryness