4-Iodo-1,2-dihydropyridin-2-one → 2,2-dimethyl-3-((R)-2-oxo-3-((S)-1-(4-(2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-6-yl)propanenitrile

Participants

Reaction Steps

The title compound was prepared from 2,2-dimethyl-3-((R)-2-oxo-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-6-yl)propanenitrile and 4-iodopyridin-2(1H)-one following a procedure analogous to that described in Example 4. LC-MS Method 1 tR=1.36 min, m/z=456(M+1); 1H NMR (CDCl3) 7.77(d, 1H), 7.43-7.32(m, 7H), 7.01(t, 4H), 5.67(q, 1H), 2.99(dd, 1H), 2.57-2.43(m, 2H), 2.32(m, 1H), 2.17(s, 2H), 1.57(d, 3H), 1.40(s, 3H), 1.33(s, 3H).

Provenance & Evidence