反应详情

1 g (0.0033 mol) of L-alanyl-L-proline ethylamide hydrobromide was dissolved in 20 ml of dry pyridine and 0.45 ml of pivaloyl chloride was added. The mixture was stirred for 1 hour at room temperature and then the pyridine was removed by evaporation. The oil was triturated with toluene, re-evaporated and then partitioned between chloroform and saturated brine. The chloroform layer was separated and dried over magnesium sulphate, filtered off and evaporated to a clear oil which crystallised on the addition of petrol. The solid was filtered off, washed with petrol and dried to yield 0.4 g (40%) of N-pivaloyl-L-alanyl-L-proline ethylamide of melting point 94°-96° C.

1. customthe pyridine was removed by evaporation
2. customThe oil was triturated with toluene
3. customre-evaporated
4. custompartitioned between chloroform and saturated brine
5. customThe chloroform layer was separated
6. dry with materialdried over magnesium sulphate
7. filtrationfiltered off
8. customevaporated to a clear oil which
9. customcrystallised on the addition of petrol
10. filtrationThe solid was filtered off
11. washwashed with petrol
12. customdried