2-Fluoroethyl trifluoromethanesulfonate → 1-(2-fluoroethyl)-4-iodopyridin-2(1H)-one

HRID 470444Notes

Reaction equation

HRID 470444 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.FC(F)(F)S(O[CH2:15][CH2:16][F:17])(=O)=O>>[F:17][CH2:16][CH2:15][N:5]1[CH:6]=[CH:7][C:2]([I:1])=[CH:3][C:4]1=[O:8]

Participants

3

Reactant 2

HCID 136389352-Fluoroethyl trifluoromethanesulfonateHCID 205825354-Iodo-1,2-dihydropyridin-2-one

Product 1

HCID 596357671-(2-fluoroethyl)-4-iodopyridin-2(1H)-one

Procedure

1-(2-fluoroethyl)-4-iodopyridin-2(1H)-one was prepared from 4-iodopyridin-2(1H)-one and 2-fluoroethyl trifluoromethanesulfonate following a procedure analogous to that described in Example 20 Step 1.

Sources & evidence

ORD record
ord-ee190eb4e72144159e3f010f6caa4751
Source dataset
uspto-grants-2014_01
Patent number
US08629138B2

Reaction notes

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