HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Chloro-4-fluoro-1,2-benzisothiazole 1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Fluoro-2,3-dihydro-1lambda6,2-benzothiazole-1,1,3-trione | HCID 14257492 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Chloro-4-fluoro-1,2-benzisothiazole 1,1-dioxide | HCID 67412709 | 93.3% |
Reaction Steps
1.1 g of 4-fluoro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide (EP291851 A2 19881123), 2 g of thionyl chloride and a catalytic amount of DMF in 6 ml of dioxane are heated under reflux for 18 hours. Then additional 2 g of thionyl chloride are added and the mixture is heated for 8 hours. The mixture is concentrated and 1.12 g of a crude solid is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629284B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-2d13b2caa01748399485e41bbe020612 |
| Source note | uspto-grants-2014_01 |