Trifluoroacetic acid → HCID 67396190, compound

Participants

Reaction Conditions

Reaction Steps

Trifluoroacetic acid (5 mL) was added slowly into a solution of 4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidine-1-carboxylic acid tert-butyl ester (compound of Example 18; 4.5 g, 10.4 mmol) in dichloromethane (25 mL) and was stirred at 25° C. for 15 h. The solvent was evaporated and the residue was extracted into chloroform (2×25 mL). The combined organic layers were washed with saturated sodium carbonate solution (2×25 mL) and water (1×25 mL). The organic phase obtained was dried over anhydrous sodium sulphate and concentrated to afford the title compound.

Provenance & Evidence