Boron tribromide → HCID 136413215, compound

Participants

Reaction Steps

Boron tribromide (0.229 mL, 2.42 mmol) was added dropwise to a cooled solution of 4-{5-[2-(3,4-Dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-1-isopropyl-piperidine (compound of Example 21; 0.15 g, 0.4 mmol) in dichloromethane (5 mL) at −78° C. The reaction mixture was warmed to room temperature and stirred for 6 h. The reaction mixture was quenched with methanol (2 mL) and the organic solvent was evaporated. The residue obtained was dissolved in 8% methanolic ammonia (5 mL) and the inorganic solid obtained was removed by filtration. The filtrate was concentrated and purified by column chromatography (silica gel, 3% methanol in chloroform) to afford the title compound.

Provenance & Evidence