Boron tribromide → HCID 136413217, compound

Participants

Reaction Steps

Boron tribromide (0.056 mL, 0,595 mmol) was added drop wise to a cooled solution of 1-benzyl-4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidine (compound of Example 30; 0.05 g, 0.12 mol) in dichloromethane (3 mL) at −78° C. The reaction mixture was warmed to room temperature and stirred for 6 h. The reaction mixture was quenched with methanol (2 mL) and the organic solvent was evaporated. The residue was suspended in methanolic ammonia (2 mL) and the undissolved solid was filtered. The filtrate was evaporated to obtain a crude product, which was purified by column chromatography (silica gel, 3% methanol in chloroform) to afford the title compound.

Provenance & Evidence