HCID 86672588, compound → HCID 178423627, compound

HRID 470675Notes

Reaction equation

HRID 470675 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]3([C@@H:15]([C:16]4[CH:21]=[CH:20][N:19]=[C:18]([Cl:22])[C:17]=4[F:23])[C@H:14]([C:24]([OH:26])=O)[NH:13][C:12]43[CH2:31][CH2:30][C:29]([CH3:33])([CH3:32])[CH2:28][CH2:27]4)[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.Cl.[NH2:35][C@H:36]1[CH2:41][CH2:40][C@H:39]([C:42]([NH2:44])=[O:43])[CH2:38][CH2:37]1>>[C:42]([C@H:39]1[CH2:40][CH2:41][C@H:36]([NH:35][C:24]([C@@H:14]2[NH:13][C:12]3([CH2:27][CH2:28][C:29]([CH3:32])([CH3:33])[CH2:30][CH2:31]3)[C@:6]3([C:5]4[C:9](=[CH:10][C:2]([Cl:1])=[CH:3][CH:4]=4)[NH:8][C:7]3=[O:11])[C@H:15]2[C:16]2[CH:21]=[CH:20][N:19]=[C:18]([Cl:22])[C:17]=2[F:23])=[O:26])[CH2:37][CH2:38]1)(=[O:43])[NH2:44]

Participants

3

Reactant 2

HCID 86672588HCID 86672588, compoundHCID 178479557HCID 178479557, compound

Product 1

HCID 178423627HCID 178423627, compoundYield 21%

Procedure

The compound (200 mg, 0.41 mmol) obtained in Step 1 of Example 17 and trans-4-aminocyclohexanecarboxamide hydrochloride (WO2005/058892) (87 mg, 0.49 mmol) were used as starting materials and treated in the same way as in Step 2 of Example 12 to give 53 mg (21%) of the title compound as a colorless solid.

Workup

  1. additiontreated in the same way as in Step 2 of Example 12

Sources & evidence

ORD record
ord-49bf89844c9d4d63928b69fb2f476642
Source dataset
uspto-grants-2014_01
Patent number
US08629133B2

Reaction notes

Loading…