HRID470675

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)CCC2(CC1)N[C@@H](C(=O)O)[C@H](c1ccnc(Cl)c1F)C21C(=O)Nc2cc(Cl)ccc21

HCID86672588

未命名化合物

HCID178479557

未命名化合物

PRODUCTS

生成物

结构：CC1(C)CCC2(CC1)N[C@@H](C(=O)N[C@H]1CC[C@H](C(N)=O)CC1)[C@H](c1ccnc(Cl)c1F)[C@]21C(=O)Nc2cc(Cl)ccc21

HCID178423627

未命名化合物

收率 21%

PROCEDURE

实验过程

The compound (200 mg, 0.41 mmol) obtained in Step 1 of Example 17 and trans-4-aminocyclohexanecarboxamide hydrochloride (WO2005/058892) (87 mg, 0.49 mmol) were used as starting materials and treated in the same way as in Step 2 of Example 12 to give 53 mg (21%) of the title compound as a colorless solid.

WORKUP

后处理

additiontreated in the same way as in Step 2 of Example 12

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-49bf89844c9d4d63928b69fb2f476642
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08629133B2
来源说明: uspto-grants-2014_01

反应 SMILES

[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]3([C@@H:15]([C:16]4[CH:21]=[CH:20][N:19]=[C:18]([Cl:22])[C:17]=4[F:23])[C@H:14]([C:24]([OH:26])=O)[NH:13][C:12]43[CH2:31][CH2:30][C:29]([CH3:33])([CH3:32])[CH2:28][CH2:27]4)[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.Cl.[NH2:35][C@H:36]1[CH2:41][CH2:40][C@H:39]([C:42]([NH2:44])=[O:43])[CH2:38][CH2:37]1>>[C:42]([C@H:39]1[CH2:40][CH2:41][C@H:36]([NH:35][C:24]([C@@H:14]2[NH:13][C:12]3([CH2:27][CH2:28][C:29]([CH3:32])([CH3:33])[CH2:30][CH2:31]3)[C@:6]3([C:5]4[C:9](=[CH:10][C:2]([Cl:1])=[CH:3][CH:4]=4)[NH:8][C:7]3=[O:11])[C@H:15]2[C:16]2[CH:21]=[CH:20][N:19]=[C:18]([Cl:22])[C:17]=2[F:23])=[O:26])[CH2:37][CH2:38]1)(=[O:43])[NH2:44]