HCID 70872006, compound → HCID 178484571, compound

HRID 470680Notes

Reaction equation

[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C@@:6]3([C:19]4([CH2:22][C:21]([CH2:25][F:26])([CH2:23][F:24])[CH2:20]4)[N:18]4[C@@H:13]([C:14](=[O:39])[O:15][C@@H:16]([C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)[C@H:17]4[C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[C@@H:12]3[C:40]3[CH:45]=[C:44]([F:46])[CH:43]=[C:42]([Cl:47])[CH:41]=3)[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[NH2:48][C@H:49]1[CH2:54][CH2:53][C@H:52]([C:55]([N:57]([CH3:59])[CH3:58])=[O:56])[CH2:51][CH2:50]1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]3([C@@H:12]([C:40]4[CH:45]=[C:44]([F:46])[CH:43]=[C:42]([Cl:47])[CH:41]=4)[C@H:13]([C:14]([NH:48][C@H:49]4[CH2:50][CH2:51][C@H:52]([C:55](=[O:56])[N:57]([CH3:58])[CH3:59])[CH2:53][CH2:54]4)=[O:39])[N:18]([C@H:17]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[C@@H:16]([OH:15])[C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[C:19]43[CH2:20][C:21]([CH2:25][F:26])([CH2:23][F:24])[CH2:22]4)[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 70872006HCID 70872006, compound

HCID 178484569HCID 178484569, compound

Product 1

HCID 178484571HCID 178484571, compoundYield 42%

Procedure

The compound (339 mg, 0.50 mmol) obtained in Step 1 of Example 164 and trans-4-amino-N,N-dimethylcyclohexanecarboxamide (144 mg, 0.85 mmol) were used as starting materials and treated in the same way as in Step 1 of Example 20 to give 178 mg (42%) of the title compound as a colorless solid.

Workup

additiontreated in the same way as in Step 1 of Example 20

Sources & evidence

ORD record: ord-5e66528d7326439c9ce379abe548af0f
Source dataset: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08629133B2

Reaction notes

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