HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperazinecarboxylic acid, ethyl ester → 5,6-Dimethoxy-3(4-carbethoxy piperazino)methylene oxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperazinecarboxylic acid, ethyl ester | HCID 8431 | — |
| Reactant | HCID 178486553 | HCID 178486553 | — |
| Product | 5,6-Dimethoxy-3(4-carbethoxy piperazino)methylene oxindole | HCID 54095422 | — |
Reaction Steps
4.0 g. of 5,6-dimethoxy-3-hydroxymethylene oxindole was reacted with N-carbethoxy piperazine as described in Example 2, except that 0.10 g. toluene sulfone acid was added as a catalyst. Yield, 3.05 g. of product, m.p. 172°-174° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04176191 |
| Source dataset | uspto-grants-1979_11 |
| ORD ID | ord-f04b5cd13a0348399248d9d826df7a49 |
| Source note | uspto-grants-1979_11 |