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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 47070Generated: October 25, 2026

1-(2-Furoyl)piperazine → 5,6-Dimethoxy-3(4-furoyl piperazino)methylene oxindole

https://huagongshe.com/reaction/47070

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Furoyl)piperazineHCID 550206—
ReactantHCID 178486553HCID 178486553—
Product5,6-Dimethoxy-3(4-furoyl piperazino)methylene oxindoleHCID 70601886—

Reaction Steps

3.0 g. of 5,6-Dimethoxy-3-hydroxymethylene oxindole was reacted with 4.0 g. N-furoyl piperazine as described in Example 2 except that 0.10 g. toluene sulfone acid was added as a catalyst. Yield 3.46 g. of product, m.p. 158°-160° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04176191
Source datasetuspto-grants-1979_11
ORD IDord-480b826da78b4e26b491233566a86978
Source noteuspto-grants-1979_11