1,4-Dioxane hydrochloride → HCID 178479250, compound

HRID 470701Notes

Reaction equation

HRID 470701 reaction equation
[ClH:1].O1CCOCC1.[O:8]=[C:9]1[O:13][N:12]=[C:11]([C@H:14]2[CH2:19][CH2:18][C@H:17]([NH:20]C(=O)OCC[Si](C)(C)C)[CH2:16][CH2:15]2)[NH:10]1>>[ClH:1].[NH2:20][C@H:17]1[CH2:16][CH2:15][C@H:14]([C:11]2[NH:10][C:9](=[O:8])[O:13][N:12]=2)[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178504281HCID 178504281, compound

Product 1

HCID 178479250HCID 178479250, compoundYield 100%

Procedure

4N hydrochloric acid/1,4-dioxane solution (3.5 ml) was added to the compound (349 mg, 1.06 mmol) obtained in Step 6 above at room temperature and the resulting mixture was stirred for 23 hours. The reaction mixture was concentrated under reduced pressure to give 234 mg (100%) of the title compound as a colorless solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5f08408c179b40a6911491286b17023b
Source dataset
uspto-grants-2014_01
Patent number
US08629133B2

Reaction notes

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