反应详情

5.00 g. of 5,6-Dimethoxy-3-hydroxymethylene oxindole, 2.5 g. acetic acid and 6.5 g. piperazine-N-carboxylic acid isobutyl ester (U.S. Pat. No. 3,635,979) in 40 ml. benzene was refluxed using a water separator to remove the water as it formed. After 20 minutes, 200 ml. benzene was added and the solution extracted with potassium carbonate and water. The benzene solution was treated with magnesium sulfate and charcoal, filtered, concentrated and the residue crystallized from isopropyl alcohol and ether to give 5.50 g. product, m.p. 195°-197° C.

1. customto remove the water as it
2. customformed
3. extractionthe solution extracted with potassium carbonate and water
4. additionThe benzene solution was treated with magnesium sulfate and charcoal
5. filtrationfiltered
6. concentrationconcentrated
7. customthe residue crystallized from isopropyl alcohol and ether
8. customto give 5.50 g