HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 5,6-Dimethoxy-3[4(3,4-dimethoxyphenyl)piperazino]methylene oxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 1-(3,4-Dimethoxyphenyl)piperazine | HCID 2736207 | — |
| Reactant | HCID 178486553 | HCID 178486553 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 5,6-Dimethoxy-3[4(3,4-dimethoxyphenyl)piperazino]methylene oxindole | HCID 54275679 | — |
Reaction Steps
3.00 g. of 5,6-Dimethoxy-3-hydroxymethylene oxindole, 2.3 g. acetic acid and 4.1 g. N-(3,4-dimethoxyphenyl)piperazine [J. Med. Chem. 10 (5) 812 (1967)] in 40 ml. benzene were reacted as described in Example 5 to give 4.67 g. product, m.p. 193°-195° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04176191 |
| Source dataset | uspto-grants-1979_11 |
| ORD ID | ord-aa565e80a5ba49e980cf4d5fcfe8b3b1 |
| Source note | uspto-grants-1979_11 |