反应详情

17.9 g of 1-bromo-2,6-dimethoxybenzene and 200 mL of acetonitrile were placed in a flask, and the resulting mixture was cooled on ice. Then, 14.7 g of N-bromosuccinimide was added. Then, while heating the reaction solution to room temperature, stirring was conducted for 8 hours. 2.39 g of N-bromosuccinimide was further added, and stirring was conducted at room temperature for 7 hours. After completion of the stirring, the solvent was distilled off under reduced pressure. Residues were dissolved in dichloromethane, and washed sequentially with sodium thiosulfate and saturated saline. An organic phase was dried with magnesium sulfate and concentrated. Residues were purified by means of silica gel column chromatography, whereby 23.2 g (yield: 95%) of colorless oil of 1,3-bromo-2,6-dimethoxybenzene was obtained.

1. temperaturethe resulting mixture was cooled on ice
2. stirringstirring
3. waitwas conducted at room temperature for 7 hours
4. distillationAfter completion of the stirring, the solvent was distilled off under reduced pressure
5. dissolutionResidues were dissolved in dichloromethane
6. washwashed sequentially with sodium thiosulfate and saturated saline
7. dry with materialAn organic phase was dried with magnesium sulfate
8. concentrationconcentrated