反应详情

Manganese dioxide (0.65 g) was added to a solution of (9-(2-(4-(hydroxymethyl)phenoxy)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-methylthiazol-4-yl)methanone (0.32 g) (example 1, step i) in DCM (20 mL) and the resulting black suspension heated under reflux for 1 h. After cooling the reaction mixture was passed through a pad of Celite. The pad was washed with DCM (2×30 mL) and the combined filtrate and washings evaporated in vacuo to give the subtitled compound as a gum. Yield 0.25 g.

1. temperaturethe resulting black suspension heated
2. temperatureunder reflux for 1 h
3. temperatureAfter cooling the reaction mixture
4. washThe pad was washed with DCM (2×30 mL)
5. customthe combined filtrate and washings evaporated in vacuo