Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 470976생성일: 2026년 10월 25일
Triethylamine → 4-(3-(4-(2-Methylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)propoxy)benzaldehyde
https://huagongshe.com/reaction/470976
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-(3-Bromopropoxy)benzaldehyde | HCID 13715789 | — |
| 반응물 | (2-Methylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone trifluoroacetate | HCID 66964121 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-(3-(4-(2-Methylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)propoxy)benzaldehyde | HCID 57989105 | — |
반응 단계
A mixture of (2-methylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone trifluoroacetate (example 4, step h) (0.244 g), 4-(3-bromopropoxy)benzaldehyde (example 8, step a) (0.15 g) and triethylamine (0.344 mL) in MeCN (2 mL) was heated at 60° C. After 16 h, the reaction mixture was evaporated in vacuo. Purification was by silica gel chromatography eluting with ethyl acetate:triethylamine, 10:1 to give the subtitled compound as an oil. Yield 0.24 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08629271B2 |
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| 출처 데이터셋 | uspto-grants-2014_01 |
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| ORD ID | ord-6fb56f44e79644ab861bddd6415b5ac9 |
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| 출처 메모 | uspto-grants-2014_01 |
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