反应详情

Benzoyl peroxide (0.05 g) was added to a mixture of 2-(3-fluoro-5-methylphenyl)acetic acid (0.518 g) and N-bromosuccinimide (0.6 g) in DCM (10 mL). The reaction was heated at reflux for 1 h. DCM (10 mL) and water (20 mL) were added and the organic phase separated. The organic layer was washed with brine (20 mL), dried over sodium sulphate, filtered and evaporated in vacuo. The residue was triturated with toluene and the resulting white solid removed by filtration. The mother liquors were evaporated in vacuo to give the subtitled compound as a white solid which was used in the next step without further purification. Yield 0.38 g.

1. temperatureThe reaction was heated
2. temperatureat reflux for 1 h
3. customthe organic phase separated
4. washThe organic layer was washed with brine (20 mL)
5. dry with materialdried over sodium sulphate
6. filtrationfiltered
7. customevaporated in vacuo
8. customThe residue was triturated with toluene
9. customthe resulting white solid removed by filtration
10. customThe mother liquors were evaporated in vacuo