反应详情

220 gm of 4,4-dimethyl-7-acetamino-2H,4H-isoquinoline-1,3-dione were added in portions to 800 ml of fuming nitric acid at -20° C. while stirring. The mixture was stirred for one hour at this temperature. Then, the reaction mixture was poured over ice, the precipitate was suction-filtered off, washed neutral with water, dried in the air, and boiled with isopropanol. After cooling, the crystals were suction-filtered off and washed with ether, yielding 222 gm (85% of theory) of 4,4-dimethyl-7-acetamino-8-nitro-2H,4H-isoquinoline-1,3-dione, m.p. 249° C. (decomp.).

1. stirringThe mixture was stirred for one hour at this temperature
2. additionThen, the reaction mixture was poured over ice
3. filtrationthe precipitate was suction-filtered off
4. washwashed neutral with water
5. customdried in the air
6. temperatureAfter cooling
7. filtrationthe crystals were suction-filtered off
8. washwashed with ether