HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 4,4-Dimethyl-7-propionylamino-8-nitro-2H,4H-isoquinoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4,4-dimethyl-7-acetamino-8-nitro-2H,4H-isoquinoline-1,3-dione | HCID 11833171 | — |
| Solvent | Propionic anhydride | HCID 31263 | — |
| Product | 4,4-Dimethyl-7-propionylamino-8-nitro-2H,4H-isoquinoline-1,3-dione | HCID 20384930 | — |
Reaction Steps
29.1 gm of 4,4-dimethyl-7-acetamino-8-nitro-2H,4H-isoquinoline-1,3-dione were refluxed for 4 hours with 50 ml of propionic acid anhydride. The mixture was then poured into ice water and neutralized with sodium bicarbonate. The obtained precipitate was purified on a silicagel column (eluant: chloroform/acetone 19:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04176184 |
| Source dataset | uspto-grants-1979_11 |
| ORD ID | ord-4924df22b6b444dcb4a340a120e8213e |
| Source note | uspto-grants-1979_11 |