Fumaric Acid → HCID 50913437, compound

Participants

Reaction Conditions

Reaction Steps

(R)-7-(2-(2-fluoro-5-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethylamino)-1-hydroxyethyl)-4-hydroxybenzo[d]thiazol-2(3H)-one (2.4 g) was dissolved in ethanol (240 mL) at 50° C. Fumaric acid (0.416 g) was added and the mixture heated under reflux until a clear solution formed. The resulting solution was allowed to cool to 60° C. and seeded with form A (example 47C) (50 mg). The resulting mixture was stirred overnight at 50° C. and then allowed to cool to RT over 3 hrs. The resulting white solid was isolated by filtration, washed with ethanol (50 mL), ether (2×200 mL) and sucked dry to give the titled compound as a white solid. Yield 2.3 g.

Provenance & Evidence