7,7-dimethyl-2-(4-benzyloxy-phenyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione → HCID 136398816, compound

HRID 47109Notes

Reaction equation

HRID 47109 reaction equation
[CH3:1][C:2]1([CH3:31])[C:11](=[O:12])[CH:10]2[C:5](=[C:6]3[N:16]=[C:15]([C:17]4[CH:22]=[CH:21][C:20]([O:23]CC5C=CC=CC=5)=[CH:19][CH:18]=4)[N:14]=[C:7]3[C:8](=[O:13])[CH2:9]2)[CH:4]=[N:3]1.[H][H]>[Pd].CO>[CH3:1][C:2]1([CH3:31])[C:11](=[O:12])[CH:10]2[C:5](=[C:6]3[N:16]=[C:15]([C:17]4[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=4)[N:14]=[C:7]3[C:8](=[O:13])[CH2:9]2)[CH:4]=[N:3]1

Participants

5

Reactant 2

HCID 706103787,7-dimethyl-2-(4-benzyloxy-phenyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dioneHCID 178418361HCID 178418361, compound

Product 1

HCID 136398816HCID 136398816, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture consisting of 2.3 gm of 7,7-dimethyl-2-(4-benzyloxy-phenyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione, 200 ml of methanol and 0.5 gm of 10% palladium-on-charcoal was hydrogenated at 50° C. at a hydrogen pressure of 5 atmospheres for 4 hours. The catalyst was then filtered off, the filtrate was evaporated to 50 ml and the precipitated crystals were suction-filtered off.

Workup

  1. filtrationThe catalyst was then filtered off
  2. customthe filtrate was evaporated to 50 ml
  3. filtrationthe precipitated crystals were suction-filtered off

Sources & evidence

ORD record
ord-e1f5dffbc63d49c5b61acc847be81e49
Source dataset
uspto-grants-1979_11
Patent number
US04176184

Reaction notes

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