反应详情

A mixture of 2-methylpropanethioamide (3.3 g) and ethyl 2-chloro-3-oxopropanoate (4.82 g) in acetone (50 mL) was heated at reflux under nitrogen for 3 hours. The mixture was cooled to room temperature and the solvent removed under reduced pressure. The crude product was purified by flash silica chromatography using 12% ethyl acetate in isohexane as solvent. Pure fractions were evaporated to dryness to afford the subtitled compound. Yield 1.6 g.

1. temperaturewas heated
2. temperatureat reflux under nitrogen for 3 hours
3. customthe solvent removed under reduced pressure
4. customThe crude product was purified by flash silica chromatography
5. customPure fractions were evaporated to dryness