反应详情

Manganese dioxide (1.36 g) was added to a solution of 2-(3-(hydroxymethyl)phenylthio)ethanol (example 65, step b) (0.29 g) in DCM (10 mL). The resulting mixture was heated at reflux for 4 h, cooled and filtered through Celite. The filter pad was washed with DCM (3×20 mL). The filtrate and washing were combined and evaporated to give the subtitled compound as a yellow gum. Yield 0.2 g.

1. temperatureThe resulting mixture was heated
2. temperatureat reflux for 4 h
3. temperaturecooled
4. filtrationfiltered through Celite
5. washThe filter pad was washed with DCM (3×20 mL)
6. washThe filtrate and washing
7. customevaporated