1-Bromo-2-Chloroethane → 7,7-dimethyl-2-(4-chlorophenyl)-5-(2-chloro-ethyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione

HRID 47119Notes

Reaction equation

HRID 47119 reaction equation
[CH3:1][C:2]1([CH3:24])[C:11](=[O:12])[CH:10]2[C:5](=[C:6]3[N:16]=[C:15]([C:17]4[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=4)[N:14]=[C:7]3[C:8](=[O:13])[CH2:9]2)[CH:4]=[N:3]1.Br[CH2:26][CH2:27][Cl:28]>>[CH3:1][C:2]1([CH3:24])[C:11](=[O:12])[CH:10]2[C:5](=[C:6]3[N:16]=[C:15]([C:17]4[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=4)[N:14]=[C:7]3[C:8](=[O:13])[CH:9]2[CH2:26][CH2:27][Cl:28])[CH:4]=[N:3]1

Participants

3

Reactant 2

HCID 78491-Bromo-2-ChloroethaneHCID 706107847,7-dimethyl-2-(4-chloro phenyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione

Product 1

HCID 706104267,7-dimethyl-2-(4-chlorophenyl)-5-(2-chloro-ethyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione

Procedure

Prepared analogous to Example 23 from 7.5 gm of 7,7-dimethyl-2-(4-chloro phenyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione and 6.9 gm of 1-bromo-2-chloro-ethane.

Sources & evidence

ORD record
ord-fe0994badf4840918bfbf48e9fbae8dd
Source dataset
uspto-grants-1979_11
Patent number
US04176184

Reaction notes

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