(3-Bromopropyl)diethylamine hydrobromide → 7,7-Dimethyl-2-(4-chloro-phenyl)-5-(3-diethylamino-propyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione dihydrochloride

HRID 47121Notes

Reaction equation

HRID 47121 reaction equation
[CH3:1][C:2]1([CH3:24])[C:11](=[O:12])[CH:10]2[C:5](=[C:6]3[N:16]=[C:15]([C:17]4[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=4)[N:14]=[C:7]3[C:8](=[O:13])[CH2:9]2)[CH:4]=[N:3]1.Br.[CH2:26]([N:28]([CH2:33][CH3:34])[CH2:29][CH2:30][CH2:31]Br)[CH3:27]>>[ClH:23].[ClH:23].[CH3:1][C:2]1([CH3:24])[C:11](=[O:12])[CH:10]2[C:5](=[C:6]3[N:16]=[C:15]([C:17]4[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=4)[N:14]=[C:7]3[C:8](=[O:13])[CH:9]2[CH2:31][CH2:30][CH2:29][N:28]([CH2:33][CH3:34])[CH2:26][CH3:27])[CH:4]=[N:3]1

Participants

3

Reactant 2

HCID 12639158(3-Bromopropyl)diethylamine hydrobromideHCID 706107847,7-dimethyl-2-(4-chloro phenyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione

Product 1

HCID 706103737,7-Dimethyl-2-(4-chloro-phenyl)-5-(3-diethylamino-propyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione dihydrochloride

Procedure

Prepared analogous to Example 23 from 3.8 gm of 7,7-dimethyl-2-(4-chloro-phenyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione and 3.1 gm of 3-diethylamino-propyl bromide hydrobromide.

Sources & evidence

ORD record
ord-377e4b5f642642d58b47f6cb5f24e511
Source dataset
uspto-grants-1979_11
Patent number
US04176184

Reaction notes

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